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As the exact cause of irritable bowel syndrome or IBS is not known, it is difficult to state whether indigestion causes irritable bowel syndrome or IBS. Indigestion is nothing but improper digestion. Due to improper digestion of food, an imbalance occurs and aggravates the symptoms of irritable bowel syndrome. Interestingly, stress too affects indigestion and irritable bowel syndrome. Depression, panic attacks, stress, and anxiety also lead to the development of both irritable bowel syndrome and indigestion. Therefore, ruling out psychological factors is never an option.