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Is Olfactory Neuroblastoma Hereditary & Is It A Disability?

Neuroblastoma (NBL) is a tumor of growing nerve cells that primarily influences babies and young kids. The infection demonstrates a varied range of medical characteristics, with certain cancers diminishing on their own, whereas others show a more antagonistic course.

Olfactory neuroblastoma (ONB) is an unusual cancerous neoplasm developing in the upper part of the sinonasal cavity. To better comprehend the hereditary bases for ONB, we present entire exome and entire genome sequencing as well as single nucleotide polymorphism array investigations in a sequence of ONB patient trials.

Is Olfactory Neuroblastoma Hereditary?

Several incidents of neuroblastoma (NBL) arise intermittently, involving persons who have no record of the disorder. Nevertheless, in 1-2 percent of instances, a vulnerability to develop neuroblastoma can be genetic from a parent.

The source of olfactory neuroblastoma is not clearly explained. No environmental or hereditary reasons have been established, while a widespread hereditary analysis of affected persons has discovered areas within genes 2, 5, 6, 7, and 20 that may be affected.

Johns Hopkins research sequence the entire genomes of cancerous cells among five people with a sporadic type of cancer in the nose and sinus cavity. During their research, they surprisingly identified certain chromosomal changes ¾ one in a chromosome associated with a tissue formation and ¾ in five of the cancers. 1,2

Researches state that there is a strong relationship to the genetic alteration in cancers however there are fairly lesser possibilities for a single chromosome to be associated with the same tumors in a different set of individuals.  According to one of the reports stated by the researchers, the deletions they founded in the chromosome that accounts for dystrophin, a rod-shaped protein that aids the anchor muscle fibers were often found in olfactory neuroblastoma cells. Neuroblastoma cells are the primary factor in causing most of the nose and sinus cavity tumors with a wide percentage of one out of every 2.5 million.

A new study indicates that almost 100 to 200 incidents are noticed every year and these cancers are treated based on the tissue samples. The study was based on sequencing the chromosomes that make up the genes and not on the spaces between the genes.3

Is Olfactory Neuroblastoma A Disability?

Although neuroblastoma is a sporadic tumor yet it is responsible for around 4% of all tumors of the nasal cavity and paranasal sinuses. In general, it is suspected to arise from neural tissue associated with the sense of smell. The condition usually progresses slowly however in rare conditions it may progress rapidly and aggressively.

Roughly half of the young kids who are treated for an increased chance of neuroblastoma and attain an early decrease will have the infection relapse. Approximately 65 percent of all kids identified with this cancer will have some metastatic infection. Recurring condition advances to the CNS as the main reason for mortality. A majority of patients with aggressive tumors cannot be cured and will die from their disease.

Because of the rarity of the disorder, no ideal chemotherapy modality has, to date, been recognized for patients with olfactory neuroblastoma. A study was conducted to make out the smell and taste disturbances among 1400 patients. Response frequencies were recorded between these patients based on their abilities to perform daily routine activities and quality of life.

Patients reporting constant olfactory damage after previously recorded olfactory loss suggest an elevated degree of disability and lower quality of life than those with the recognized outcome of an olfactory compromise. The olfactory senses have important functions in early identification of fire, gas leaks and spoiled foods.4,5


  1. Olfactory neuroblastoma – Genetic and Rare Diseases – NIH https://rarediseases.info.nih.gov/diseases/2197/olfactory-neuroblastoma/cases/22730
  2. Genetic and molecular alterations in olfactory neuroblastoma: implications for pathogenesis, prognosis and treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239575/
  3. Johns Hopkins researchers find genetic cause of olfactory neuroblastoma https://www.news-medical.net/news/20190228/Johns-Hopkins-researchers-find-genetic-cause-of-olfactory-neuroblastoma.aspx
  4. Olfactory neuroblastoma (esthesioneuroblastoma) https://www.uptodate.com/contents/olfactory-neuroblastoma-esthesioneuroblastoma
  5. Olfactory neuroblastoma: Report of a case and review of the literature https://www.sciencedirect.com/science/article/pii/0278239189902887

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Team PainAssist
Team PainAssist
Written, Edited or Reviewed By: Team PainAssist, Pain Assist Inc. This article does not provide medical advice. See disclaimer
Last Modified On:March 12, 2020

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