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A very large pimple can also be called as an acne nodule if it is set deeper into the skin and is not mouthed at the surface layer of the skin. Usually the acne nodule appears to be a large swelling developing from under the surface layer of the skin. Among the kinds to acne that usually attack the skin like pustules, papules and cystic acne, acne nodule is the most difficult kind because it often leads to scaring of the skin permanently.