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If you ask if sinus infection can lead to pneumonia, it should be said that there is a possibility of this. However, the chances are very rare. In extreme cases, when sinus infection does spread to other body parts and does not get treated within a few days, the chances are high that the infection would spread in areas or organs near the sinus, such as the brain or the eyes. It is very rare and unlikely that the sinus infection would spread to the lower respiratory tract, especially to the lungs.