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At times, numbness in big toe may seem harmless condition but it can lead to problems that may adversely affect your coordination and balance. Some of the causes of numbness in big toes includes restricted circulation of blood, vitamin B12 deficiency, cervical spondylosis, compression of the nerve, gout, peripheral neuropath, diabetes, and Raynaud’s Disease. The best treatment options for numbness in big toe depend on the underlying causes.