Prurigo nodularis itself is not contagious. Prurigo nodularis is an inflammatory skin disease that is quite difficult to treat. There is a mild to moderate, success rate of treatment in case of Prurigo nodularis. Usually the treatment is done with a combination of medications. Antihistamines, Corticosteroid creams, Capsaicin creams, and Topical anesthetics are the treatments used to get rid of the itchiness and to reduce the inflammation and the lesions.