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Keratolytic Winter Erythema also often termed as Oudtshoorn disease, Oudtshoorn skin, and Erythrokeratolysis Hiemalis is a rare form of autosomal dominant skin disease. It is identified as a cyclical disruption of epidermal keratinisation, which predominantly affects the palmoplantar skin, causing patches of thickened skin, redness and peeling of the skin on the soles and palms. Know the causes, symptoms, treatment, risks and prevention of keratolytic winter erythema.