The implication of high oestradiol concentration and a large number of oocytes in OHSS on the outcome of assisted reproduction are not evident in the clinical records.
In an analysis of in vitro fertilization (IVF) cycles consisting of conventional IVF, intracytoplasmic sperm injection and oocyte donation cycles show that although the mean fertilization rate has closer resemblance to other groups, yet the proportion of the retrieved oocytes that produced embryos of a quality suitable for transfer fell significantly with increasing numbers of recovering oocytes.1
Does Ovarian Hyperstimulation Affect Egg Quality?
The influence of the ovarian hyperstimulation syndrome in embryo quality and implantation and pregnancy rate:
Certain researches indicate that ovarian hyperstimulation can concede implantation rates in assisted fertilization care phases. Other studies believe that ovarian hyperstimulation syndrome does not impact implantation rates or the quality of both oocytes and embryo. The purpose of this study was to evaluate the embryonic quality, the implantation, and pregnancy rates of patients with ovarian hyperstimulation syndrome by comparing them to a control group without OHSS.
High dosage drugs are given to the patients undergoing fertility treatment to stimulate the ovaries. This may sometimes result in chromosomal abnormalities in their eggs eventually resulting in failed pregnancies and children getting affected with down syndrome (a genetic disorder caused by an error in cell division called “nondisjunction)
A study was conducted on 1900 patients with an indication for intracytoplasmic sperm injection in which 150 cases had ovarian hyperstimulation syndrome and the rest did not. Both the short and long protocols were used. Human chorionic gonadotropin hormone was induced and a minimal of 3 follicles reached 19mm in diameter. M2 eggs (egg is in the second phase of meiosis and is mature) were injected 4 hours after oocyte retrieval.
These hormonal drugs are typically induced to encourage the ovaries to produce high energy eggs that have the potential to fertilize and implant in the womb. However, there is an equal downside of using this hormone therapy, this is called hyperstimulation which makes the female severely ill.
For women under 35 years of age, the doctor recommends only mild stimulation, nevertheless, when these females don’t gestate within that timeline and also in women over 35 years of age, larger doses of hormones (hyperstimulation) are administered. Ovarian hyperstimulation often results in chromosomal abnormalities and leads to unsuccessful pregnancy and stillbirth.2,3
How Do You Get Rid Of Ovarian Hyperstimulation Syndrome When Pregnant?
Although no treatment can reverse ovarian hyperstimulation syndrome, it will generally improve with time. Doctors suggest treatment to improve symptoms and prevent complications. Ovarian hyperstimulation syndrome usually resolves on its own within a week or two or slightly extensive if you’re in the prenatal stage.
Treatment is intended to improve your symptoms, decreasing ovarian activity and preventing complications. Mild ovarian hyperstimulation syndrome symptoms, such as fluid retention and ovarian discomfort, can be managed by drinking plenty of fluids and also electrolyte-rich drinks to prevent dehydration. In addition to that, these females are recommended not to carry out strenuous exercises because certain exercises could lead to ovarian damage.
Diagnosis of ovarian hyperstimulation is often based on:
Physical Exam: Physical findings of ovarian hyperstimulation syndrome include right or left lower quadrant pain below the umbilicus, as well as edema. Daily physical examination should consist of measuring the patient’s weight and fluid accumulation.
Ultrasound – Ultrasound examination will usually show ovaries 10 to 12 cm in diameter filled with multiple luteal cysts. This is typically done through a vaginal ultrasound.
Blood Test- This measure hormone levels for signs of ovarian hyperstimulation syndrome. Specific blood examinations permit your doctor to verify for anomalies in your plasma and whether your kidney function is being damaged because of OHSS.4,5
- High doses of IVF drugs may cause harm to eggs https://www.theguardian.com/science/2011/jul/04/ivf-drugs-women-chromosome-eggs
- Ovarian Hyperstimulation Syndrome – Reproductive facts https://www.reproductivefacts.org/news-and-publications/patient-fact-sheets-and-booklets/documents/fact-sheets-and-info-booklets/ovarian-hyperstimulation-syndrome-ohss/
- Ovarian hyperstimulation syndrome – Diagnosis and Treatment https://www.mayoclinic.org/diseases-conditions/ovarian-hyperstimulation-syndrome-ohss/diagnosis-treatment/drc-20354703
- Ovarian hyperstimulation syndrome (OHSS): how to deal with it https://theduff.co.uk/ovarian-hyperstimulation-syndrome-ohss-ivf/
- Treating Ovarian Hyperstimulation Syndrome https://progyny.com/education/fertility-medication/treating-ovarian-hyperstimulation-syndrome/
- Coping Methods For Ovarian Hyperstimulation Syndrome
- How To Diagnose Ovarian Hyperstimulation Syndrome & What Is The Best Medicine For It?
- What Are The First Symptoms Of Ovarian Hyperstimulation Syndrome?
- What Is The Best Treatment For Ovarian Hyperstimulation Syndrome?
- What Leads To Ovarian Hyperstimulation Syndrome & Can It Be Cured?