This article on Epainassist.com has been reviewed by a medical professional, as well as checked for facts, to assure the readers the best possible accuracy.

We follow a strict editorial policy and we have a zero-tolerance policy regarding any level of plagiarism. Our articles are resourced from reputable online pages. This article may contains scientific references. The numbers in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers.

The feedback link “Was this Article Helpful” on this page can be used to report content that is not accurate, up-to-date or questionable in any manner.

This article does not provide medical advice.


Fraley’s Syndrome: Causes, Symptoms, Diagnosis, Treatment

Fraley’s Syndrome– This is a pathological condition of the kidney in which there is obstruction of the superior infundibulum of the kidney due to a crossing renal artery branch resulting in pain in the flanks and other symptoms. In this article, we will discuss in detail about the causes, symptoms, and treatment for Fraley’s Syndrome.

Fraley's Syndrome

What Is Fraley’s Syndrome?

As stated, Fraley’s Syndrome is a pathological condition of the kidneys in which the superior infundibulum of the kidney gets obstructed by a crossing branch of the renal artery resulting in distension and dilatation of calyx causing hematuria and nephralgia also called as ipsilateral flank pain.

Causes of Fraley’s Syndrome

Fraley Syndrome is usually caused by renal vessels, which are present in the upper segmental artery. If observed radiologically, these vessels reveal a well-defined filling defect in the infundibulum. The upper calyx looks distended.

Symptoms of Fraley’s Syndrome

Diagnosis of Fraley’s Syndrome

In order to confirm the diagnosis of Fraley Syndrome, The main tests performed are intravenous urography, retrograde pyelography, and angiography. Hippuran imaging is done to look for functional and excretory changes in superior infundibulum and is known to be an effective way to diagnose Fraley’s Syndrome. Ultrasound can also be done to confirm the diagnosis of Fraley’s Syndrome.

Treatment For Fraley’s Syndrome

The only treatment by far for treatment of Fraley Syndrome is an upper pole nephrectomy, which relieves the symptoms completely.


  1. Urology Annals. “Fraley’s Syndrome: A Rare Cause of Flank Pain.” https://www.urologyannals.com/article.asp?issn=0974-7796;year=2020;volume=12;issue=4;spage=395;epage=397;aulast=Khandelwal.
  2. Journal of Clinical Imaging Science. “Fraley’s Syndrome: A Case Report and Review of the Literature.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686835/.
  3. Radiopaedia. “Fraley Syndrome.” https://radiopaedia.org/articles/fraley-syndrome.
Pramod Kerkar, M.D., FFARCSI, DA
Pramod Kerkar, M.D., FFARCSI, DA
Written, Edited or Reviewed By: Pramod Kerkar, M.D., FFARCSI, DA Pain Assist Inc. This article does not provide medical advice. See disclaimer
Last Modified On:September 14, 2023

Recent Posts

Related Posts