MGUS or Monoclonal Gammopathy of undetermined significance, the condition is named because the significance of Monoclonal Gammopathy was not known and the condition was taken for granted. Later the scientists have established a strong link between the occurrence of Monoclonal Gammopathy and multiple myeloma. In patients suffering from monoclonal gammopathy of undetermined significance, there is the presence of M. protein.

Advertisement

Plasma cells which are a type of white blood cells start producing one type of antibody. There will not be a sign of infection but still, antibodies are seen in the blood. Monoclonal gammopathy of undetermined significance as such does not produce any sign and symptoms’. But this silent disease can progress to deadly cancers such as multiple myeloma certain lymphomas, or a rare condition called amyloidosis.

Advertisement

Can You Be Cured Of MGUS Or Monoclonal Gammopathy Of Undetermined Significance?

It is estimated that about 1% of the population suffering from MGUs progress to multiple myeloma. People who are diagnosed with monoclonal gammopathy of undetermined significance are monitored yearly for the amount of M proteins. This will help in determining the life expectancy of the patients.

There is no cure for monoclonal gammopathy of undetermined significance, but only careful monitoring and controlling the symptoms is important. It is not advised for the population to include M-protein test in the routine blood analysis as the chances of developing the disease is less but the patients who are at risk are advised depending upon medical condition. Once the diagnosis of M- protein is established the cause of the presence of M protein and the symptoms for the underlying disease are to be established to confirm the progression of the disease to malignancies. If the patients are diagnosed with multiple myeloma then the patient has 5 years to survive.

Advertisement

The exact cause of the disease is not known, but the prevalence is high in the old population and in African Americans, immune compromised patients and there is a genetic link for people with monoclonal gammopathy of undetermined significance.

There is no way to prevent the occurrence of monoclonal gammopathy of undetermined significance, as still there is no scientific evidence for the factors responsible for MGUS. It as such does not have any treatment. Few people have bone loss and bone fracture, such patients are given supplements to strengthen bone to maintain bone integrity and prevent fracture. Medicines are prescribed to increase bone density. The commonly prescribed medication for symptomatic treatment of MGS is alendronate (Binosto, Fosamax), ibandronate (Boniva), risedronate (Actonel, Atelvia), and zoledronic acid (Reclast, Zometa).

There is no treatment for monoclonal gammopathy of undetermined significance; doctors will advise patients diagnosed with MGUS to monitor the levels of M-protein the blood. There will be a regular evaluation of your blood to check the M-protein levels. This will provide guidance about the progression of the disease to any serious medical illnesses.

Monoclonal gammopathy of undetermined significance can just be monitored for its progression to any serious disease so as to start symptomatic treatment of the possible disease. It is a condition were patient watching is important. Treatment of symptoms cannot be started unless the disease has progressed. Your doctor might keep an eye on the development of sign and symptoms such as pain, weakness, fever, night sweats, headache, dizziness, nerve pain, or changes in vision or hearing, improper blood reports, anemia, bleeding, swollen lymph nodes, liver or spleen, or dizziness. Some people also develop heart and kidney problems. Lifestyle changes like including curcumin (turmeric powder), avoiding meat, diet soda and processed food can be helpful in slowing the progression of the disease to some extent.

Conclusion

Monoclonal gammopathy of undetermined significance as such does not produce any harm or sign and symptoms of the disease. But there will be a slow and steady increase in the levels of M protein the blood which can be indicative of underlying lymphoproliferative disorders. There is no cure for monoclonal gammopathy of undetermined significance, but diet modification can be helpful in increasing the survival rate and slowing the progression of the disease to malignant conditions.

Also Read:

Pramod Kerkar

Written, Edited or Reviewed By:

, MD,FFARCSI

Pain Assist Inc.

Last Modified On: February 14, 2019

This article does not provide medical advice. See disclaimer

Advertisement

Sign Up for Our Newsletter

We'll help you live each day to the healthiest