What Is The Best Medicine For MGUS Or Monoclonal Gammopathy Of Undetermined Significance?

What Is The Best Medicine For MGUS or Monoclonal Gammopathy of Undetermined Significance?

Medicines for monoclonal gammopathy of undetermined significance are prescribed according to the symptoms available. MGUS impairs the density of the bone and causes bone fractures. So doctors recommend bisphosphonate to elevate the density of the bone. These medicines are ibandronate, alendronate, risedronate and zoledronic acid.

Monoclonal gammopathy of undetermined significance (MGUS) is a benign condition that leads to the appearance of an abnormal protein (M protein) in the blood. These proteins are formed from the white blood cells. They are produced by plasma cells in the bone marrow. These proteins are formed when the body reacts to combat any infection. They are formed instead of antibodies. They circulate in the blood and remain at stable levels for years without causing a symptom. They lead to slow degeneration of the bone resulting in low bone density and bone fractures.

The incidence of monoclonal gammopathy of undetermined significance is more seen in the old people who are above 70 years. Its incidence is highest in the age of 85 years or above. It is detected incidentally in routine blood tests done for other health problems. Males are more affected than females. Exposure to pesticides can risk you the concentration of M proteins in the blood remains stable and constant nearly for 25 years. It does not need any treatment as it does not cause a major effect on health. It may proceed slowly to serious complications like myeloma, lymphoma, etc.

Symptoms of Monoclonal Gammopathy of Undetermined Significance

Most cases of MGUS are without any sign or symptom. This disease is diagnosed accidentally in a blood test done for other conditions. In rare cases, the following symptoms are present-

  • Tingling sensation
  • Numbness due to nerves involvement
  • Weakness in the nerves
  • Rashes or irritation in the skin
  • Bone loss or bone fractures

Treatment For Monoclonal Gammopathy Of Undetermined Significance

Monoclonal gammopathy of undetermined significance does not represent any sign or symptom. There is no need for treatment. It has slow progress to serious complications such as lymphoma, myeloma, etc. So, it is essential to monitor the levels of M protein to keep an eye on the steady progress of the disease. It is recommended that frequent check-ups should be done if there is a high risk of development of complications.

MGUS is treated by following ways-

Wait And Watch– the disease does not represent symptoms, so it does not need treatment. The doctor keeps a watch on the signs and symptoms of the development of the disease. Initially, the symptoms are monitored in every 3-4 months, then it may be done in every 6-8 months when symptoms do not develop. These symptoms include

  • Weakness and tiredness the whole day
  • Pain in the whole body
  • Fever and night sweats
  • Unexplained weight loss
  • Bleeding
  • Headache
  • Dizziness
  • Changes in one’s vision or hearing abilities
  • Anemia or other blood disorders
  • Enlargement of the lymph nodes, liver or spleen
  • Problems related to heart and kidney.

The best treatment for monoclonal gammopathy of undetermined significance is to wait and watch the symptoms of MGUS to progress to serious complications.

Monoclonal gammopathy of undetermined significance (MGUS) is a condition that develops in the body by increasing age. It is determined by the presence of abnormal proteins in the blood. These proteins are produced when the body’s immune system fight against infections and they are produced instead of antibodies. This disease does not cause a significant impact on health. It can be associated with other diseases at the same time. It develops mostly in old people and has very gradual progress to serious diseases.

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