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Doctors have until now failed to identify the exact cause of IBS & Constipation problem. However, they have identified many factors, which would play major role. Walls of human intestine remain present in the form of lines with muscular layers, which contract as well as relax in coordinated rhythm while the food moves from the stomach to reach at intestinal tract and later on, to the rectum. In order to treat the problem of IBS and constipation, doctors have mentioned two special medications, Lotronex or Alosetron and Lubiprostone or Amitiza.