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Wearing nail polish can be harmful for skin and nails. Toluene, formaldehyde, and phthalate are the biggest risk-causing chemicals present in the nail polish or nail paint. Acetone in the nail polish remover can cause irritated eyes, skin, and throat. Acetone can also lead to headache and dizziness. Methacrylic acid is present in nail primer and can lead to irritation in the eyes, skin, nose, mouth, and throat. Methacrylic acid present in nail polish can also cause difficulty in breathing.