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What is the Cause of Chronic Kidney Disease or CKD?

Chronic kidney disease or CKD contains all conditions, which cause damage to the kidneys and reduce the ability of humans to stay in healthy condition. When kidney problem becomes worse, wastes may create high levels in the blood and cause you to feel sick. Individuals may develop various complications, like low blood count i.e. anemia, high blood pressure, poor nutritional health, weak bones and damage to the nerves. Moreover, kidney problem boosts your risk related to blood vessel and heart diseases. These problems may take place slowly relatively over a long period.

Chronic kidney disease or CKD may take place because of high blood pressure, diabetes and various other forms of disorders. However, detection in advance may help a lot in keeping chronic kidney problems worse. With the progression of kidney disease, patients suffer from kidney failure and they require to undergo either dialysis or kidney transplantation to maintain the healthy life.

Key Facts on Chronic Kidney Disease or CKD

  • A large number of adults in different regions of the world deal with chronic kidney disease or CKD, while other people remain at the increased risk to the problem.
  • Early detection of the problem may help a lot in the prevention of progressing kidney problems towards kidney failure.
  • Heart problem is the prime cause of death for chronic kidney disease or CKD patients.
  • Glomerular filtration rate constitute the best possible estimation of the actual kidney function.
  • Hypertension in humans leads to chronic kidney disease or CKD.
  • Persistent protein-urea or protein in the urine indicates chronic kidney disease or CKD problem in humans.
  • Individuals suffering from hypertension and diabetes or people with family history associated with kidney failure remain at relatively higher risks of chronic kidney disease or CKD.
  • Doctors diagnose the problem of chronic kidney disease or CKD in humans based on simple tests i.e. urine albumin and serum creatinine as well as blood pressure.

What is the Cause of Chronic Kidney Disease or CKD?

What is the Cause of Chronic Kidney Disease or CKD?

Until now, doctors have failed to identify the exact cause of the chronic kidney disease or CKD. However, any disease or health condition leads to the damage of blood vessels or any other related structure in kidneys may result in kidney problems. Based on this fact, common causes of chronic kidney disease or CKD problem are-

  • Diabetes or High Blood Sugar Levels: High levels of blood sugar caused from diabetes may cause severe damages to the kidneys’ blood vessels. If the level of the blood sugar remains at high for many years, the damage reduces the normal functions performed by kidneys gradually.
  • Hypertension or High Blood Pressure: Uncontrolled form of high blood pressure or hypertension causes damage to the blood vessels, which may further result in severe kidney damages. In addition, chronic kidney disease or CKD further increases blood pressure, because of which high blood pressure causes further damages to the function of kidneys even when any other medical condition leads to the problem.

Other Conditions for Chronic Kidney Disease or CKD Problems

Other than this, there are a few other conditions, which lead to chronic kidney disease or CKD problems-

  • Glomerulonephritis: Glomerulonephritis, which implies a group of health problems, which lead to the inflammation and damage to the filtering units of human kidney. These disorders are also the common forms of kidney problems.
  • Inherited Problems: Polycystic kidney problems and other similar types of inherited problems may create big cysts in kidneys and cause damages to the nearby tissues.
  • Malformations: Malformations usually take place whenever a baby develops in the womb of its mother. For instance, narrowing may take place that avoids normal urine outflow and thereby, flow back of the urine towards the kidney.
  • Lupus and Other Similar Problems: Lupus and other similar problems may affect the overall immune system of humans in an adverse way.


  1. National Kidney Foundation. (2021). Chronic Kidney Disease. https://www.kidney.org/atoz/content/about-chronic-kidney-disease
  2. Mayo Clinic. (2021). Chronic Kidney Disease. https://www.mayoclinic.org/diseases-conditions/chronic-kidney-disease/symptoms-causes/syc-20354521
  3. National Institute of Diabetes and Digestive and Kidney Diseases. (2021). Chronic Kidney Disease (CKD). https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd
Team PainAssist
Team PainAssist
Written, Edited or Reviewed By: Team PainAssist, Pain Assist Inc. This article does not provide medical advice. See disclaimer
Last Modified On:September 27, 2023

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