Where Does Lymphoma Start In The Body?

Lymphoma refers to the cancer of lymphatic system and it affects a specific type of white blood cells called lymphocytes. Lymphocytes cells remain present in different lymph nodes, thymus, spleen, bone marrow and various other parts in our body.

Where Does Lymphoma Start In The Body?

Where Does Lymphoma Start In The Body?

Lymphoma type of cancer starts initially in the white blood cells, also referred as lymphocytes. However, as it remains present in one’s bloodstream, it may spread and/or metastasize to various other organs of the human body.

Spread of Lymphoma in Patients

We know that lymphatic tissue remains connected with different regions of our body. Hence, in case cancer cells develop within the lymphatic system, they may spread easily from their exact locations to many other organs and tissues, along with others remain present outside of the immune system. According to experts, lymphoma usually starts in white blood cells, but later on spreads to lungs, bone marrows and liver. Considering this fact, doctors have categorized two different types of lymphoma disease in patients, which include the following-

Hodgkin’s Lymphoma

In case of Classic Hodgkin’s Lymphoma or Hodgkin’s Lymphoma, cancer often starts by causing infection in a particular lymph node and later on, goes to the another one present in a particular order. This type of lymphoma is according to the presence of a special type of cells named Reed-Sternberg cells. About 75 percent of total patients diagnosed with this type of disease, are able to recover completely and 90 percent of individuals diagnosed at the initial phase may live more than 10 years without any sign related to relapse of the problem.

Stage of the problem during its diagnosis has a critical role in planning for the treatment. In some of the cases, doctors initially give chemotherapy to their patients and later on, introduce young cells from other bone marrows i.e. bone marrow transplantation to increase the chances of living of their patients. Bone marrow transplantation-based treatment is essential for all patients, whose problems come back even after chemotherapy procedure.

Non-Hodgkin’s Lymphoma

In case of Non-Hodgkin’s Lymphoma, tumors take place in disparate type of lymph nodes by skipping a few of the specific nodes. Especially, these types of lymphoma problems affect T and B cells. It often accounts for about 90 percent of the lymphoma cases and 4 percent of all sorts of cancers take place among US people.

Approximately 50 percent of 60 percent with Non-Hodgkin’s type of lymphoma are able to live about 5 years or even more without recurrence of the disease or any of the symptoms. Even though cure and treatment of the problem depends on many factors, the best treatment for Non-Hodgkin’s type of disorder is to determine the specific stage of the disease and tissue classification procedure.

When a person suffers from lymphoma cancer, lymphocytes undergo changes and become out of their control. In case of lymphoma, cancer cells remain present within the lymphatic system consisting of lymph nodes, bone marrow, stomach, spleen, skin and intestines.

If we talk about normal lymph nodes, they are small and possess bean structures to trap cells containing waste materials and poisons. Even they act as cells reservoirs capable to supply microorganism-fighting type of antibodies. Tube type vessels are responsible to carry lymph i.e. a white/milk colored fluid to connect lymph nodes with one another.

Lymph helps lymphocytes to circulate. However, when lymphocytes multiple in an abnormal way, they lead to the formation of masses and enlarging of lymph nodes. Some of the lymphomas affect bone marrows, while interfere with the formation of blood cells.


To conclude, we should say that lymphoma starts from white blood cells but later on, it spreads to various other organs of the patients’ body. However, the areas and the extent of spread depend solely on the disease’s stage and the type of lymphoma present.

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Pramod Kerkar, M.D., FFARCSI, DA
Pramod Kerkar, M.D., FFARCSI, DA
Written, Edited or Reviewed By: Pramod Kerkar, M.D., FFARCSI, DA Pain Assist Inc. This article does not provide medical advice. See disclaimer
Last Modified On:September 1, 2021

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