How Effective is Glyburide & What are its Side Effects?

Do not take glyburide if you are having type 1 diabetes, if you are using bosentan (tracleer) or if you having a condition known as diabetic ketoacidosis (ask your doctor to treat you with insulin)

How Effective is Glyburide?

How Effective is Glyburide?

Glyburide is a diabetes medicine that is administered orally and assists in regulating blood sugar levels. Glyburide is utilized effectively in treatment of type 2 diabetes and is not used in treating type one diabetes.

Before using Glyburide, you should notify your doctor if you experience allergic reaction to sulfa medicines, been using cghlorpropamide (diabinese) or insulin, if you have an enzyme deficit (G6PD), or you suffer from nerve problem, hemolytic anemia (shortage of red blood cells), kidney or liver diseases.

You should be careful not allow your blood sugar to get too low. Your blood sugar may drop if you exercise too much, skip meals, taker alcohol or when stressed. The signs include weakness, headache, sweating, hunger, irritability, tremor or confusion. Always carry glucose tablet or hard candy if you have low sugar levels. You can also take milk or orange juice. Make sure that your family or friends know how to assist you in case of an emergency.

Before Using Glyburide

Do not take glyburide if you are allergic to it or:

  • When using bosentan (Tracleer);
  • When you have type 1 diabetes
  • When in a condition of diabetic ketoacidosis (ask your physician to treat you with insulin).

To be safe with glyburide, notify your doctor when you have:

  • Shortage of red blood cells (hemolytic anemia)
  • An enzyme shortage known as glucose-6-phosphate dehydrogenase deficiency (g6pd);
  • Nerve problems interfering with body functions
  • Kidney or liver illness
  • If you used chlorpropamide within the last 14 days.
  • If you experience allergic reactions to sulfa medicines.
  • When taking chlorpropamide (diabinise) or insulin.

Some oral diabetes medicines can escalate the dangers of severe heart complications. However, if you do not treat your diabetes you may destroy your organs or heart. Ask your doctor about the advantages and disadvantages of using glyburide.

It is not established whether glyburide can hurt unborn child. Notify your medical advisor if you are or are planning to get pregnant while taking glyburide. Your physician may prefer usage of insulin during pregnancy.

It is not clear whether this medicine can hurt a nursing child or if it can get into breast milk. Do not breastfeed while taking glyburide.

What is the Recommended Dosage of Glyburide?

General Adult Dose of Glyburide for Treating Diabetes Type 2:

First dose: Administer glyburide orally 1.5 milligrams (micronized) or 2.5 milligrams (standard) once daily with morning meal.

Maintenance dose: Administer glyburide orally 0.75 to 12 milligrams (micronized) or 1.25 to 20 milligrams in 1 or 2 separated doses.

Maximum dose: Take 12 milligrams (micronized) or 20 milligrams (standard) per day.

General Geriatric Dose of Glyburide for treating Diabetes Type 2:

Initial dose: Administer glyburide orally 0.75 to 1.5 milligrams (micronized) or 1.25 to 2.5 milligrams (standard) once daily.

What are the Side Effects of Glyburide?

Seek emergency medical assistance if you experience symptoms of allergic reactions to glyburide such as breathing problems, hives or swelling of your throat, tongue, face and lips.

Stop glyburide intake and notify your physician immediately if you have the severe side effects of glyburide:

  • Unfamiliar bleeding (bleeding gums, nose bleeding) or bruising
  • Abrupt feeling sickness, weakness, chills, fever, mouth and throat sores, swollen or red gums and difficulty in swallowing.
  • Severe glyburide symptoms of liver complications such as itching, upper stomach pains, lack of appetite, fatigue, clay colored stools, dark urine and jaundice.
  • Signs of reduced levels of sodium in the body like confusion, headache, serious weakness, distorted speech, feeling unstable, loss of coordination.

Common side effects of glyburide include:

  • Heartburn
  • Stomach upsets
  • Nausea
  • Feeling sick
  • Joint and muscle aches are also side effects of glyburide.
  • Unclear vision
  • Slight rash or redness of the skin.
Pramod Kerkar, M.D., FFARCSI, DA
Pramod Kerkar, M.D., FFARCSI, DA
Written, Edited or Reviewed By: Pramod Kerkar, M.D., FFARCSI, DA Pain Assist Inc. This article does not provide medical advice. See disclaimer
Last Modified On:June 10, 2019

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