Reviewed By: Pramod Kerkar, MD, FFARCSI

MGUS or Monoclonal gammopathy of undetermined significance is a rare benign condition marked by the presence of abnormal proteins in the blood. These proteins are called monoclonal proteins, M proteins or paraproteins. These proteins are produced in the bone marrow and have a negligible effect on the health. The disease is asymptomatic. It cannot be cured and neither be prevented. It has a tendency to progress to cancer can be delayed to some extent.

Prevention Of MGUS Or Monoclonal Gammopathy Of Undetermined Significance

There is no effective way known to prevent the development of monoclonal gammopathy of undetermined significance. There is no vaccine known to prevent the disease or its progress to cancer. Its causes are not clear. It can occur due to genetic causes or due to environmental factors. It develops with a series of lots of events. If those events are disrupted, then MGUS can be aborted.

Primary Prevention

Monoclonal gammopathy of undetermined significance can be primarily prevented if its risk factors are known. The person who has risk factors such as old age, African or American African race, and family history of MGUS can prevent the disease by avoiding exposure to pesticides or certain chemicals that can promote the disease. Wearing proper equipment should be used to protect oneself while handling chemicals or pesticides. It may reduce the risk of developing monoclonal gammopathy of undetermined significance. Many times, the disease remains undetected because it is asymptomatic and accidentally discovered through a blood test.

Secondary Prevention

There is no vaccine or other methods to prevent the progress of monoclonal gammopathy of undetermined significance to cancer. It cannot be prevented with medicines. If a person has MGUS, he should have regular checkups and make some lifestyle changes. This can help to delay the progress of the disease. Regular screening can detect cancer earlier to treat the condition. This also disrupts the production of paraproteins. The lifestyle changes that can act as secondary prevention are-

  • Introduction of fresh fruits and vegetables
  • Regular exercises
  • Avoidance of deep-fried food and fast food
  • Proper sleep pattern
  • Management of stress

MGUS or monoclonal gammopathy of undetermined significance is a condition characterized by the production of monoclonal proteins or M proteins or paraproteins. They are formed from white blood cells in bone marrow. They circulate in the blood. They are produced in response to infection when the body begins to produce them in place of antibodies. This disease is a slowly progressive disease and the presence of M proteins does not harm the health of a person. It does not require any treatment. The old people are more prone to develop in this disease. It erodes bone and reduces its density leading to bone fractures. It may take 25 years or more to progress to serious complications like multiple myeloma, lymphomas, light chain deposition disease, etc. This disease is often associated with other diseases. This disease cannot be cured.

However, its progress to cancer can be delayed.

Risk Factors For Monoclonal Gammopathy Of Undetermined Significance

The risk factors that can promote the development of monoclonal gammopathy of undetermined significance are-

  • Its incidence increases with increasing age. It develops in old people whose age is 70 years or above. Its incidence is highest in the age of 85 years or above.
  • Constant exposure to pesticides also possesses the risk of developing MGUS.
  • The disease is more common in Africans, and African -Americans than white people.
  • Males are more affected than females.
  • There are high chances of developing monoclonal gammopathy of undetermined significance if there is a family history of this disease.

Conclusion

Monoclonal gammopathy of undetermined significance is a premalignant condition that can progress to cancer. There is no specific way to prevent the disease and its progress. Primary prevention of MGUS can be somewhat achieved by limiting the risked person to chemicals and pesticides. There is no vaccine available to prevent its progress, but it can be delayed by lifestyle changes and regular screening.

Also Read:

Pramod Kerkar

Written, Edited or Reviewed By:

, MD,FFARCSI

Pain Assist Inc.

Last Modified On: February 14, 2019

This article does not provide medical advice. See disclaimer

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