What’s up with this NMN? Hoax or not?

In June 2018, the World Health Organization (WHO) released the 11th edition of the International Classification of Diseases, which for the first time includes aging. The identification of aging as a disease allows for new research into cutting-edge medicines to prevent or treat age-related disorders such as cancer, cardiovascular and metabolic disease, and neurodegeneration. There has been a lot of research done on nutrient sensing systems, such as mTOR (mammalian target of rapamycin), which controls protein synthesis and cell growth, AMPK (activated protein kinase), which detects low energy states, and sirtuins, a family of seven proteins that play an important role in DNA expression and aging and only function in conjunction with NAD+ (nicotinamide adenine dinucleotide).

NAD+ is produced and regulated in the body by a symphony of interconnected alterations known as NMN Pathways in the Human Body

Nicotinamide adenine dinucleotide (NAD+) is a molecule that is formed when vitamin B3 is present. The fact that NMN is a potent NAD+ precursor is also widely established. A different molecule termed NAD+ is a precursor of NMN. This may play a key role in delaying the aging process, according to research. Our bodies naturally become more vulnerable to several illnesses, heart ailments, obesity, and other issues as we age. Even while NMN may be found in trace levels in several fruits and vegetables, including avocados, broccoli, cabbage, edamame, and cucumbers, most of the NMN in mammals is created from vitamin B3 in the form of nicotinamide. The key enzyme is nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamide to NMN in both intracellular (iNAMPT) and extracellular forms (eNAMPT).

Several research have shown numerous benefits of NMN brand, including:

• Reduced chance of obesity: Increased NMN levels stimulate the metabolic system, improving the body’s ability to turn food into energy. However, this should be done in conjunction with an active lifestyle and a well-balanced diet.
• Reducing the risk of getting heart disease Your heart will continue to beat constantly for the rest of your life. It creates a substantial amount of energy, thus it needs as much NAD+ as it can get.
• Enhancing physical fitness and muscular endurance: Our bones and muscles need glucose and fatty acids to function correctly. Their body absorption is facilitated by NAD+. Without it, everything moves more slowly and your muscular endurance diminishes.

Our metabolisms depend on mitochondria, which are enhanced by NAD+ produced by NMN supplements. They serve as the cell’s batteries by converting glucose into energy. Without them, cells would exhaust their available energy and die.

When used in large doses, several NAD-boosting supplements have been linked to adverse reactions such nausea, diarrhea, flushing, stomach pain, and indigestion. At doses of 500 mg and above, however, study participants who used NMN supplements reported no harmful side effects. On the Joe Rogan podcast, Harvard Professor David Sinclair claimed to take up to one gram of NMN every day with just the odd upset stomach as a side effect, although his experiences only apply to him.

Based on the clinical trials, a human study done in Japan at dosages up to 500 mg indicated no harmful effects, however a study on endurance at doses up to 1200 mg revealed issues. Although study is ongoing, there are currently no severe safety concerns concerning NMN supplements.

The availability of inexpensive and fake imitations, on the other hand, is by far the most important safety issue. The same claims can be made about things that are far less expensive. Many of these have been diluted with other substances and are not entirely pure NMN. These may not be safe if the manufacturer was unsure about what was inside. Look for recognized items that have undergone independent safety certification.