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Understanding Cotard Delusion : Symptoms, Causes, Diagnosis and Treatment of Walking Corpse Syndrome

What is Cotard Delusion?

Cotard delusion is a rare mental disorder in which a person has a belief that they do not exist, or have lost organs, blood, or body parts. It is also termed walking corpse syndrome.

The delusion can vary in severity from mild to severe and may include a person believing them being immortal and not needing food or sleep.

Why Cotard delusion occurs is not yet well understood but is associated with other mental health conditions including depression, bipolar disorder and schizophrenia.(1) Its occurrence is also linked with brain injuries and other neurological conditions including Parkinson’s disease and epilepsy.

A person can suffer from extreme conditions due to Cotard delusion but can get better with treatment.

Causes of Cotard Delusion

The exact cause of occurrence of Cotard delusion is still not well understood but it has a link with some conditions related to the brain disorder including schizophrenia.(1)

There are a few possible conditions that may lead to Cotard delusion:

  • Neurological Disorders: There are a few neurological conditions that Cotard delusion is linked to. These include Parkinson’s disease, epilepsy, and migraine. These conditions are known to affect the ability of the brain to process sensory information, distorting perception.
  • Mental Health Conditions: Cotard delusion can be linked with certain mental health conditions including depression, anxiety, bipolar disorder, and schizophrenia. These conditions are known to affect the perception of reality and contribute to the development of Cotard delusion.
  • Brain Injuries: Cotard delusion can also occur due to physical injuries to the brain including traumatic brain injury, tumors, and stroke. There can be changes the brain function due to these injuries that may lead to delusion.
  • Infections: Infection especially in the brain may lead to delusions and other neurological symptoms.
  • Drug Use: Certain drugs including antipsychotic medications and hallucinogens can cause delusions contributing to the cause of Cotard delusion.
  • Environmental Factors: Stressful life events including loss of loved ones or social isolation may act as a trigger for Cotard delusion.

Role of Brain Chemistry in Cotard Delusion

The exact role of brain chemistry in causing Cotard delusion is not known but it is researched that the activity of certain chemicals in the brain may lead to the development of this condition.

  • Dopamine: It is a neurotransmitter that has a role in reward and motivation. Overactivity of this chemical may lead to delusions including Cotard delusion.(2)
  • Serotonin: Serotonins regulate mood, appetite, and sleep. Low levels of serotonin may be associated with depression, which is a common co-occurring condition along with Cotard delusion.
  • Glutamate: Glutamate plays a role in learning and memory. Studies suggest that an imbalance in glutamate may lead to delusions including Cotard delusions.(3)
  • Norepinephrine: It is a neurotransmitter that is involved in the body’s response to stress. High levels of norepinephrine are linked to anxiety and paranoia which may contribute to Cotard delusion.
  • Gamma-Aminobutyric acid: It is a neurotransmitter playing a role in stress and anxiety. An imbalance of Gamma-Aminobutyric acid is associated with a range of mental health conditions including depression and anxiety.

However, the exact role of brain chemistry in the development of Cotard delusion may vary in people.

Symptoms of Cotard Delusion

The symptoms of Cotard delusion may vary in severity. It involves a distorted perception of the self and reality.

The symptom of Cotard delusion include:

  • Believing In Self-Death: A person with Cotard delusion may believe that they are dead already or their organs are dead.
  • Belief in Immortality: Some cases of Cotard delusion may have a belief that they are immortal and can never die.
  • Denial of one’s existence: People with Cotard delusion may deny their own existence.
  • Loss of Interest: A person may lose interest in activities they used to enjoy earlier and may have difficulty in finding pleasure in life.
  • Feeling Disconnected: A person may feel disconnected from the world around them and may feel like living in a dream.
  • Physical Symptoms: There may be physical symptoms including insomnia, fatigue, and changes in appetite.

Diagnosis of Cotard Delusion

Cotard delusion can be diagnosed by a doctor by speaking with the person about how they feel. As it can be a symptom of an underlying condition, identifying the cause is also important. If schizophrenia is suspected psychiatric assessment may be recommended, which involves answering a series of questions about the mental state of a person. The mental health professional may use the diagnostic criteria from DSM-5 to determine if a person has Cotard delusion.(4)

Following are the steps involves in diagnosing Cotard delusion:

  • Medical History: The doctor may discuss the medical history of the patient, which may involve questions about the onset, duration, and severity of the symptoms. The presence of any other mental health condition will be looked for.
  • Physical Examination: The doctor also conducts a physical examination to look for the presence of any underlying physical health condition.
  • Psychological Assessment: Standardized psychological evaluation is conducted to know about an individual’s cognitive and emotional functioning.

Based on the calculations the conditions in the differential diagnosis with similar symptoms are ruled out.

Treatment of Cotard Syndrome

The treatment of Cotard syndrome is tailored to meet every person’s needs. The treatment may involve medication and psychotherapy. Some may even need hospitalization.

Antipsychotic and Antidepressant Medications

Antipsychotic medications are used to treat psychotic symptoms associated with Cotard delusion including delusion and hallucinations. These medication work by regulating the levels of dopamine in the brain. These medications work by blocking dopamine receptors in the brain, which can help alleviate hallucinations and delusions.

Antidepressant medications treat the depression and anxiety that are co-occurring with Cotard delusion. These medications regulate serotonin along with other neurotransmitters.

Electroconvulsive Therapy (ECT)

Electroconvulsive therapy (ECT) is another treatment option for Cotard delusion. Electroconvulsive therapy (ECT) involves inducing a seizure in the brain through the use of electrical currents. While the exact mechanism of action is not fully understood, it is thought that ECT can help alleviate symptoms by altering the chemical activity in the brain. Electroconvulsive therapy (ECT) is typically reserved for cases where medication has proven ineffective or for patients who are at high risk of harming themselves or others.

Psychotherapy– Cognitive-Behavioral Therapy (CBT)

Psychotherapy includes cognitive behavior therapy or supportive therapy in which a person is taught coping skills and strategies to manage symptoms. It can also be helpful in addressing any underlying emotional and psychological issues. Cognitive-behavioral therapy (CBT) is a non-pharmacological treatment option for Cotard delusion. CBT involves working with a therapist to identify and challenge negative thought patterns that may be contributing to the delusional beliefs. CBT can help patients to develop coping strategies for managing their symptoms and improve their overall quality of life.


In severe cases of Cotard delusion, a person may be hospitalized to ensure safety and well-being. Their intensive treatment may be provided and there may be continuous monitoring to stabilize the symptoms.

Treatment of Cotard delusion may require a collaborative approach between friends, family, and mental health professionals. The main goal of the treatment is to reduce the symptoms and improve the quality of life.

It is important to note that while these treatments can be effective in alleviating symptoms, they may also have side effects. Common side effects of antipsychotic medications include weight gain, sedation, and movement disorders. ECT can cause short-term memory loss and headaches, while CBT may cause temporary anxiety or distress.

The effectiveness of these treatments in treating Cotard delusion can vary depending on the individual and the underlying cause of the delusion. Some patients may respond well to medication, while others may require a combination of medication and therapy. ECT is typically reserved for severe cases where other treatments have failed.

Prognosis of Cotard Delusion

The prognosis of Cotard delusion may depend on the following factors:

  • Severity of symptoms
  • A person’s response to treatment
  • Underlying medical and psychological conditions

Early diagnosis may lead to better outcomes. Proper treatment may be helpful in achieving improvement in symptoms and quality of life. The symptoms should be properly monitored by a mental health professional for a better treatment outcome.


Cotard delusion is a rare and complex psychiatric condition that is characterized by a delusional belief of being nonexistent, having lost the body parts or organs, or being immortal. It can also be a symptom of various underlying conditions including brain injury, neurological disorders, and mental illness. Diagnosis should be done by a mental health professional and treatment involves medication and psychotherapy.

The prognosis depends on the underlying cause and severity of the symptoms. With appropriate care and support a person is able to recover and lead a normal life.

Team PainAssist
Team PainAssist
Written, Edited or Reviewed By: Team PainAssist, Pain Assist Inc. This article does not provide medical advice. See disclaimer
Last Modified On:February 19, 2023

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