How Effective is Kyprolis, Know its Side Effects, Dosage

Kyprolis can affect the lungs and heart. If you have chest pain, shortness of breath ( even while lying down or with mild exertion), swelling of feet or hands, pounding heartbeats, wheezing, feeling like you want to pass out, gasping for breath or blue colored look of skin and lips, cough with foamy mucus, then you should call the doctor immediately.

Kyprolis is a medicine which is effectively used to treat cancer mainly in reducing and stopping the growth of cancer cells in the body.

Multiple myeloma can also be effectively treated by kyprolis. This medicine kyprolis is sometimes used together with other medicines to treat relapsed multiple myeloma.
After at least two other cancer medicines have failed is when kyprolis is usually used.

Do not use it if you have allergies to kyprolis. To ensure you are safe to use kyprolis, tell your doctor if you have the following conditions:

• Kidney disease or if on its dialysis
• High blood pressure, heart disease
• Abnormal liver function tests or liver disease.

An unborn baby can be harmed by kyprolis. Effective birth control should be used to prevent pregnancy while using kyprolis. This should apply to both men and women because kyprolis use by both man and woman may cause birth defects.

Women should keep using the birth control pills for at least a month after the last dosage of kyprolis. Men should keep using birth control pills for at least 90 days after their final dosage. If a pregnancy occurs while either the father or the mother is using this medicine then you need to tell the doctor immediately.

It is not known or confirmed if kyprolis passes through breast milk which would harm the baby, therefore tell your doctor if you are breast feeding a child.

• Kyprolis is injected in a vein through an IV by a healthcare provider.
• Kyprolis is given in a cycle of 28 day treatment. There are certain days of the circle you can get an injection.
• The numbers of treatment cycles you receive are determined by your doctor.
• There are medications given to prevent certain side effects when receiving kyprolis. After and before the injections, you are needed to drink plenty of liquids.
• If you have ongoing diarrhea or vomiting, you need to call your doctor immediately or if you are sweating becomes unusual. One can be easily dehydrated when on medication.
• Regular tests should be carried out to ensure that kyprolis does not cause any harmful effects. The results of these tests may delay your cancer treatment.

Kyprolis for multiple myeloma usual Dose for adults:

The first cycle: take 20 milligrams/m2 over 2 to 10 minutes on the initial two days for each treatment week for 3 weeks for example Days 1, 2, 8, 9, 15. This should be followed by a rest period of 12 days which are days 17 and 28.

Maintenance kyprolis dosage: 27 milligrams/m2 intravenously and this should begin in cycle 2 only if the first cycle dose was tolerated and continuing for the subsequent cycles as tolerated. For cycle 2 and the subsequent cycles, the dosing schedule remains the same.

If you have signs of an allergic reaction you should get emergency medical help. The allergic reactions may be: breathing difficulties, hives, swelling or the face, tongue, throat and lips.

Some side effects of kyprolis may occur within a day after the injection. If you feel dizzy, weak, light headed, nausea, fever, sweaty, pain in joints and muscles, chest tightness, headache, back pain, breathing troubles or swelling in the face then you should tell your doctor immediately.

Call your doctor immediately if you have the below severe side effects of kyprolis:

• Lighted headed feeling like feeling to pass out
• Unusual bleeding, easy bruising or any other bleeding that will not stop
• Confusion, headache, loss of vision, change in mental status, seizure(convulsions)
• Diarrhea, vomiting, weakness, stomach pain, blood in your stool
• Vomit that looks like coffee grounds or coughing blood.
• Hear problems- pounding heartbeats, chest pain or pressure, fluttering in the chest, nausea, pain spreading to the shoulder or jaw, sweating
• Liver problems- loss of appetite, upper stomach pain, jaundice (yellowing of the eyes and skin) dark urine
• Low blood cell counts- chills, fever, flu-like symptoms, mouth sores, swollen gums, rapid heart rate, skin sores, weakness, pale skin
• Lung problems- swelling of feet and hands, shortness of breath even while lying down or with mild exertion, wheezing, blue colored skin and lips, gasping for breath, cough with foamy mucus
• Signs of stroke- sudden severe headache, sudden weakness or numbness especially on one side of the body, vision problems or balance, slurred speech
• Sign of blood clot in lung- sudden cough, chest pain, rapid breathing, wheezing
• Sign of blood clot in the leg- swelling, pain, warmth, redness in the leg
• Sign of tumor cell breakdown- pain in lower back, little or no urinating, blood in urine, numbness or tingly feeling around the mouth, muscle tightness or weakness, slow or fast heart rate, weak pulse.

Common side effects of kyprolis:

• Bruising, fever, pale skin, or other low blood cell counts signs
• Nausea
• Diarrhea
• Feeling tired.