Crestor which is also known as Rosuvastatin is part of HMG CoA reductase inhibitors group of drugs. It is used in reduction of triglycerides and low-density lipoprotein (toxic cholesterol) present in the blood, at the same time raising levels of High- density lipoproteins (good cholesterol) in the blood.

Crestor or rosuvastatin is prescribed for children over eight years and adults to assist in reduction of triglycerides and low-density lipoproteins and to reduce the rate at which fat builds up in blood vessels.

Crestor or rosuvastatin is also effective in minimizing possible chances of heart attack, stroke and heart related complications in people suffering from diabetes and coronary heart illness or other factors.

Crestor or rosuvastatin is also utilized in treatment of high cholesterol that is genetically transmitted from one parent (heterozygous type) or from both parents (homozygous type). For heterozygous case, this drug can be prescribed for children of eight years of age and above while for homozygous cases children of at least seven years can use Crestor.

How Does Crestor or Rosuvastatin Work?

Crestor or rosuvastatin enhances the degeneration of fats and cholesterol by blocking an enzyme found in the liver, which is responsible in generation of excess fats and LDL in the body.

Effectiveness of Crestor or Rosuvastatin

Effectiveness of Crestor or Rosuvastatin

Rosuvastatin together with dietary restriction has been proven to be effective in treatment of people with high possibility of getting cardiovascular disease if initial diagnosis revealed high cholesterol levels.

Crestor or rosuvastatin is also effective in treating hypertriglyceridemia, mixed dyslipidemia, primary hyperlipidemia and other lipid related problems.

Crestor or rosuvastatin is also effective in treatment of genetic disorders like heterozygous and homozygous hypercholesterolemia in children of above eight years and seven years respectively, who are having high cholesterol level complications. This drug is effective in such cases if combined with other fats and cholesterol lowering agents and diet restriction.

Crestor is also utilized in reducing the pace at which atherosclerosis advances in adult patients. Crestor or rosuvastatin is also used as a sole preventive drug of cardiovascular disease, to minimize the possibility of conditions such as angina, stroke and heart attack in patients suffering from diabetes, heart illness, high or low blood pressure, low HDL-C or people with history of heart diseases in their lineage and factors such as old age.

  • Strictly take a single dose of crestor within 24 hours, with or without food.
  • Separate administration of Crestor from antacids (give two hours apart).
  • Crestor and anti acid drugs should be taken separately, 2hours apart.
  • Stop taking the drug and seek medical advice incase of kidney failure, acute muscle pain, trauma, severe infections, major surgery, metabolic disorders, severe electrolyte or uncontrolled seizures.
  • You should stick to the TLC diet recommended by NCEP while administering Cestor.
  • People of Asian origin to take low dose; they are more sensitive to Crestor.
  • Stop smoking and do exercises when taking Crestor.
  • Dosage from one person to another. Take between 10mg to 20mg per day for adults and For Asian or children of above 8 years take 5mg per day. After two or four weeks you can change your dose depending with cholesterol taste results.

The response and effectiveness of crestor or rosuvastatin is amazing. Effectiveness of this drug may be realized after four hours of oral administration. However, changes in your cholesterol can be evident after 2 to 4weeks of using Crestor. It may take four weeks before your cholesterol levels are reduced.

What is the Recommended Dosage for Crestor or Rosuvastatin?

Dosage of Crestor or Rosuvastatin for Adults with Hyperlipoproteinemia:

  • Initial dosage - between 5mg to 10mg of Crestor once in every 24 hours .
  • Maintenance dosage - take between 5mg to 40mg of Crestor once in every 24 hours.

Dosage of Crestor or Rosuvastatin for Adults With Elevated LDL Hyperlipoproteinemia:

  • Initial dosage - take between 5 mg to 10 mg of Crestor once, in every 24 hours.
  • Maintenance dosage - take between 5mg to 40mg of Crestor once in every 24 hours.

Crestor or Rosuvastatin Dosage for Adults with Elevated LDL and VLDL Hyperlipoproteinemia:

  • Initial dosage - take between 5 mg to 10 mg of Crestor once in every 24 hours.
  • Maintenance Dosage - take between 5mg to 40mg of Crestor once in every 24 hours.

Dosage of Crestor or Rosuvastatin for Adults with Type Elevated VLDL Hyperlipoproteinemia:

  • Initial dosage - take between 5mg to 10 mg of Crestor once in every 24 hours.
  • Maintenance dosage - take between 5mg to 40mg of Crestor once in every 24 hours.

Dosage of Crestor or Rosuvastatin for Adults with Atherosclerosis Condition:

  • Initial dosage - take between 5 mg to 10 mg of Crestor once in every 24 hours.
  • Maintenance Dosage - take between 5mg to 40mg of Crestor once in every 24 hours.

What are the Side Effects of Crestor or Rosuvastatin?

Seek immediate medical attention if you experience breathing difficulties, hives, and swelling of your lips, tongue or face after taking Crestor.

In very rare occasions crestor or rosuvastatin can cause breakdown of the skeletal muscle tissues resulting to kidney failure. Contact your doctor immediately if you are experiencing severe muscle aches, yellowing of skin or eyes, dark colored urine, weakness or you are too fatigued.

Crestor or rosuvastatin just like any other drugs has side effects in patients of between 18years to 60years of age. You may experience the following contraindications if you are not having other medical conditions or not on any other drugs.

  • Muscle fatigue, tenderness and pain are common side effects of crestor or rosuvastatin but it must be monitored and checked to prevent severe muscle aches known as rhabdomyolysis which is the damaging of muscle cells. These side effects are more serious in people of over 65years of age and are using drugs such as ARVs, gemfibrozil, cyclosporine and those taking alcohol or suffering from kidney illnesses.
  • Other common side effects include headache, abdominal pain, constipation, nausea and lack of energy.
  • Prolonged use of crestor or rosuvastatin may cause confusion, loss of memory or partial amnesia but these effects are reversible when the dosage is halted.
  • Crestor may interact with other drugs such as protease inhibitors, cyclosporine, warfin and gemfibrozil.
  • Liver function may be affected with changes in liver tests or jaundice. This needs discontinuation or reduction of dosage.

Other Side Effects of Crestor or Rosuvastatin Include:

  • Fatigue.
  • Muscle pains and headache.
  • Loss of memory, confusion and forgetfulness.
  • Liver symptoms like jaundice, dark urine or stomach pains.
  • Kidney complications such as difficulty in urinating.
  • Contact your doctor immediately for more guidance in case of these signs.

Conclusion

Crestor or rosuvastatin is an effective drug in reduction of cholesterol levels in the body but the side effects involved limits its dosage prescription, especially to people of Asian origin.

Written, Edited or Reviewed By:

, MD, FFARCSI

Last Modified On: July 27, 2017

Pain Assist Inc.

Pramod Kerkar
  Note: Information provided is not a substitute for physician, hospital or any form of medical care. Examination and Investigation is necessary for correct diagnosis.

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