How Effective is Entresto? It’s Dosage & Side Effects

The use of Entresto is strictly restricted in case of pregnant women. Make sure that you inform your doctor about pregnancy as it can be very harmful even life threatening for the unborn baby. Entresto is also not recommended in case of people suffering from diabetes.

How Effective is Entresto?

How Effective is Entresto?

Entresto is used as a medication for effectively managing high blood pressure. Entresto is composed of valsartan and sacubitril mixed together in a fixed ratio. When the blood pressure increases in the body, Entresto increases the amount of some proteins in the body which widens the blood vessels. Thus, the blood pressure is reduced. Entresto is also effective in reducing congestive heart failure.

Valsartan which is a part of Entresto belongs to the category of angiotensin II receptor blockers (ARB) that prevent the blood vessels from contracting, thus ensuring a proper flow of blood. Entresto is an effective medication for people with chronic blood pressure problems. It keeps the risk of emergency due to heart failure away. It is generally given along with other medicines of blood pressure.

What is the Recommended Dosage of Entresto?

Recommended Dose for Congestive Heart Failure in Adults: Initially, a patient should be given a dosage of 51 mg of Entresto, twice a day. The ratio of Sacubitril and Valsartan should be 49:51 milligrams. The recommended maintenance dosage of Entresto should be 97 mg of Sacubitril and 103 mg of Valsartan, twice a day.

What are the Side Effects of Entresto?

It is important to identify the signs of Entresto side effects and seek immediate medical attention. The common signs of Entresto side effects are swelling in tongue, lips, face and throat and difficulty in breathing. African Americans have increased risk of Entresto side effects.

Some other symptoms of Entresto side effects are as follows:

  • Lacking physical strength
  • Light headedness
  • Weak pulse or low heart rate
  • Lack of sensation in body
  • Kidney not functioning properly leading to kidney problems is also a side effect of Entresto.

In some cases, it may also cause cough and dizziness.

Caution Before Taking Entresto

The use of Entresto should be avoided in case of people having allergic to sacubitril or valsartan (Diovan). It is also important to check for allergy to some other medications such as enalapril, lisinopril, captopril, benazepril, ramipril, quinapril, perindopril, moexipril, fosinopril, trandolapril (Accupril, Lotensin, Prinivil, Mavik, Vasotec, and others); candesartan, azilsartan, irbesartan, telmisartan, eprosartan, olmesartan, losartan, valsartan (Atacand, Benicar,Avapro, Edarbi, Diovan, Teveten, Micardis, and others).

You must wait for at least 36 hours after taking any of the above mentioned ACE inhibitor medication before trying Entresto. For diabetic patients, Entresto cannot be combined with medications like Tekamlo, Amturnide, Valturna and Tekturna. People who are already having any kidney problem must also avoid this medication. Keep your doctor informed about any of the existing problems with liver, kidney or heart.

Entresto can be very harmful for the pregnant women. Thus, it is important that you tell your doctor about your condition in case you become pregnant after starting the treatment. Entresto can even be life threatening to the unborn baby. Use birth control measures to avoid accidental pregnancy. Scientists are still trying to find out if use of Entresto is harmful for newborns feeding on mother’s milk as it is not sure if sacubitril and valsartan can pass into the breast milk. However, it is better to avoid using medicines in breast feeding mothers.

What other Drugs Will Affect Entresto?

There are certain medicines that must not be used along with Entresto. Thus, you need to avoid Entresto if you are taking any of the diuretic pills, lithium, aliskiren, potassium containing medicines, and nonsteroidal anti-inflammatory drugs (NSAIDS) such as indomethacin, celecoxib, spirin, naproxen (Aleve), ibuprofen (Advil, Motrin), diclofenac, meloxicam.

Also Read:

Pramod Kerkar, M.D., FFARCSI, DA
Pramod Kerkar, M.D., FFARCSI, DA
Written, Edited or Reviewed By: Pramod Kerkar, M.D., FFARCSI, DA Pain Assist Inc. This article does not provide medical advice. See disclaimer
Last Modified On:August 10, 2017

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