What Causes HCM (Hypertrophic Cardiomyopathy)?

In Hypertrophic cardiomyopathy (HCM) the muscular walls of the heart’s ventricles get thickened. In the region of thickened muscle, the muscle cells can seem disarranged. HCM usually influences the left ventricle (the fundamental pumping chamber), and especially the septum (region of muscle amidst the heart, which separates the left and right sides). Though, it can likewise attack the right ventricle.

The normal thickness of the left ventricle muscle wall in a grown-up is 12 mm; however, in HCM condition the thickness is minimum 15 mm.

Hypertrophic Cardiomyopathy

The thickening of the muscle makes the ventricle harder, that makes it difficult for the heart to relax and fill with blood, and contract to pump out the blood. Contingent upon the amount of thickening and the area, the volume of the ventricle and how much blood it can support might be standard or might be lessened and include less blood than normal.

HCM is also known by few other names, which are:

  • Asymmetric septal hypertrophy
  • Hypertrophic obstructive cardiomyopathy
  • Hypertrophic nonobstructive cardiomyopathy
  • Idiopathic hypertrophic subaortic stenosis (IHSS)
  • Familial hypertrophic cardiomyopathy.


Symptoms can show up at any phase of a person’s life, from the teenage time to middle or older age. An individual can endure hypertrophic cardiomyopathy and never feel any indications, yet conceivable symptoms are:

What Causes HCM (Hypertrophic Cardiomyopathy)?

HCM is generally hereditary. It is caused by one or more than one gene transformations inside the proteins of heart muscle cells.

The cells extend and become disordered in their order, as opposed to making straight lines. This is alluded to as “myofiber disarray” and it certain times causes arrhythmia. The thickened ventricles may, in the long run, hinder the flow of blood from the heart, and the illness is known as obstructive hypertrophic cardiomyopathy.

At the point when the flow of blood from the heart isn’t fundamentally limited, the ventricular thickening can, in any case, diminish the chamber’s ability to store blood and subsequently its capacity to pump blood throughout the body. This is called the non-obstructive hypertrophic cardiomyopathy.

The condition is generally genetic and there is 50% chance that every child destined to have a parent with hypertrophic cardiomyopathy will acquire the mutation for this condition.

HCM likewise can happen with time as a result of aging. Ailments, like hypertension, diabetes or thyroid can cause hypertrophic cardiomyopathy too.

Complications of HCM (Hypertrophic Cardiomyopathy)

Arrhythmias  HCM can cause unusual heart rhythms called arrhythmias as the disturbed muscle cells may influence the ordinary electrical signaling in the heart that regulates the pulse. This disturbance causes an alteration in the heart’s rhythm, and it beats too slow, too fast or irregularly.

Heart failure – If the heart isn’t working adequately and it fails to pump enough blood, at the correct pressure, to address the body’s requirements lead to heart failure.

Mitral valve sickness- Seldom, the stiffened heart muscle may affect the mitral valve of a heart, making it out of shape and troublesome for the heart valve to close. This can make a flawed valve and lead to symptoms of heart failure.

Sudden cardiac death – This can occur because of serious arrhythmias, for example, ventricular fibrillation, which can make the heart stop beating i.e. a heart failure. Though the risk of sudden cardiac death is less in HCM.

How is Hypertrophic Cardiomyopathy Diagnosed?

HCM is analyzed on the basis of your medical history, symptoms, family history, a physical exam, and echocardiogram outcomes. Extra tests may comprise of blood tests, chest X-ray, electrocardiogram, cardiovascular catheterization, CT scan, MRI, and exercise stress test.


Treatment of HCM (Hypertrophic Cardiomyopathy) relies upon whether there is shrinking in the path that blood drives to leave the heart known as the outflow tract, how the heart is working; and if suffering from arrhythmias. Treatment is done for forestalling symptoms and complications and consists risk identification, lifestyle changes, medication, consistent follow-up, and methodology as required.

Also Read:

Pramod Kerkar, M.D., FFARCSI, DA
Pramod Kerkar, M.D., FFARCSI, DA
Written, Edited or Reviewed By: Pramod Kerkar, M.D., FFARCSI, DA Pain Assist Inc. This article does not provide medical advice. See disclaimer
Last Modified On:October 20, 2018

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